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About
FAQ
MetaBlog
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When “Treatment-Resistant Depression” Is actually Data-Deficient
Paula Smith 2/22/26 Paula Smith 2/22/26

When “Treatment-Resistant Depression” Is actually Data-Deficient

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Microglia: How the Brain Senses Stress, Metabolism, and Inflammation
Paula Smith 2/5/26 Paula Smith 2/5/26

Microglia: How the Brain Senses Stress, Metabolism, and Inflammation

Microglia are the brain’s immune support cells and play a key role in how stress, sleep, metabolism, and inflammation affect mental health. Learn how microglial imbalance contributes to brain fog, anxiety, fatigue, and low mood—and what helps restore balance.

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Why Your Depression Persists Despite Antidepressants, Therapy, and "Doing Everything Right"
Paula Smith 1/30/26 Paula Smith 1/30/26

Why Your Depression Persists Despite Antidepressants, Therapy, and "Doing Everything Right"

Approximately 30% of people with major depression have treatment-resistant depression—failure to respond to at least two antidepressant trials. The problem isn't that you're resistant to treatment. Your depression may be resistant to treatments that don't address the underlying inflammatory and metabolic dysfunction driving your symptoms.

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Why You Can't Sleep: How Metabolic Dysfunction Disrupts Your Circadian Rhythm
Paula Smith 1/16/26 Paula Smith 1/16/26

Why You Can't Sleep: How Metabolic Dysfunction Disrupts Your Circadian Rhythm

Sleep medications stop working because they don't address why your brain can't sleep naturally. Learn how blood sugar crashes, cortisol dysregulation, inflammation, and nutrient deficiencies disrupt circadian rhythm—and why fixing metabolism is the path to sustainable sleep.

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Why You Can't Focus: The Metabolic Root Causes Behind Low Motivation
Paula Smith 1/2/26 Paula Smith 1/2/26

Why You Can't Focus: The Metabolic Root Causes Behind Low Motivation

Your labs came back "normal" but you still can't focus. The problem isn't low dopamine. It may be metabolic dysfunction breaking down your brain's signaling.

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